Transcription in Prokaryotes

This course will enable the students to understand the basic mechanism of transcription and its regulation in prokaryotes. The course covers the organization of prokaryotic genes, operon concept, structure of RNA polymerase, it’s mode of action, types of control system and regulation of expression of prokaryotic genes. The topic is simplified with different examples of lac operon, trp operon, ara operon, etc.


Genetic Disorder

•Genetic disorder are due to alterations or abnormalities in the genome of an organism.
•Genetic disorders occur when a mutation affects your genes or when you have the wrong amount of genetic material.
•Genes are the basic unit of heredity. They hold the genetic information in the form of DNA which can be translated into useful Proteins to carryout life processes. These genes undergo a mutation, which changes the protein does not work properly.
•Genes are made of DNA , which contain instructions for cell functioning and the characteristics that make you unique
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•It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality.
•The mutation responsible can occur spontaneously before embryonic development or it can be inherited from two parents who are carriers of a faulty gene (autosomal recessive ) or from a parent with the disorder (autosomal dominant).

Recombinant DNA Technology

The course discusses about Recombinant DNA Technology which is a breakthrough invention in the field of biotechnology. It also covers the scope and impact of Recombinant DNA Technology on human life with several customized products. The Development of technology and generation of product has multiple steps and understanding these steps are being covered in this course with a discussion of biotechnology application at the end. By the end of this course, student will be able to understand following aspects of biotechnology: 

1. Basic metabolic pathways and their regulation. 

2. Microbial growth kinetics with an emphasis on fermentation

3. Basic molecular biology tools used in biotechnology. 

4. Basic methodology for product recovery and analysis.